![]() These include a series of tightly coordinated and precisely timed morphogenetic processes, including epithelial-to-mesenchymal transitions (EMTs see Glossary, Box 1), collective cell migration (see Glossary, Box 1) and mesenchymal-to-epithelial transitions (METs see Glossary, Box 1). These approaches have yielded a wealth of new data indicating that, although endoderm organs may vary in their form and function, both within and across species, they share many mechanisms that orchestrate their earliest stages of development. However, in recent years, studies of the endoderm have been aided by the identification of robust molecular markers that identify endoderm cells, coupled with high-resolution time-lapse and, in some cases, deep-tissue imaging techniques. ![]() Moreover, in amniotes, the squamous epithelial nature of the nascent endoderm epithelium makes gene expression hard to localize by mRNA in situ hybridization. Furthermore, nascent endoderm cells are not easily morphologically distinguishable from adjacent tissues in many model organisms. For example, the endoderm represents approximately 3.5% of all cells of the mouse embryo-proper at midgestation ( Nowotschin et al., 2019). it being internal) and difficulties in visualizing it during normal and perturbed development, but also because it comprises just a small proportion of the bulk of cells in an embryo at any given stage. Investigating the endoderm had been hindered, in part due its inaccessibility (i.e. The overall average revenue per download for Lineage M to date currently stands at $279, compared to $57 for Lineage 2: Revolution.Īnother Lineage mobile game from NCSoft, Lineage 2 M, is set to launch in Q4 2019.Until recently, the behaviour of endoderm cells during early stages of development had been relatively understudied and poorly understood. Japan ranked sixth in terms of downloads by country, despite representing the second most revenue of any region. ![]() Indonesia came in second with 3.2 million downloads, or 10.4 percent, and the United States came in third with 2.8 million downloads, or 9.1 percent. South Korea was once again the largest driver of downloads, generating 9.2 million downloads, or 30.4 percent of the total. Android accounts for 22.6 million, or 74.2 percent of the total, while iOS has generated 7.8 million downloads, or 25.7 percent. Lineage 2: Revolution has been downloaded nearly four times more than Lineage M, picking up 30.5 million unique installs since launch. Taiwan came in second with one million, or 13 percent of the downloads, and Japan came in third with 245,000 or three percent of the downloads. South Korea made up the lion’s share of unique installs, with 6.8 million, or 83 percent of the total number of downloads. Of these, Android represented seven million downloads, or 86 percent of the total, while iOS accounted for nearly 1.2 million unique installs, or 14 percent. Lineage M has been downloaded almost 8.2 million times to date. Japan, however, made a significant contribution as the second highest grossing country, accounting for $410 million of sales, or 23.6 percent, while Taiwan users spent $112 million, or 6.4 percent. Much like Lineage M, users in South Korea spent the most on Lineage 2: Revolution, generating $993 million in revenue, or 57 percent. It took $1 billion from player spending on Google Play, or 61 percent, with iOS users paying out $678 million, or 39 percent. Lineage 2: Revolution also brought in the majority of its revenue from Android, though the platform split was not as one-sided. Taiwan ranked second with $203 million, or 8.9 percent, and Hong Kong ranked third with $23 million, or 1 percent. South Korea, where the Lineage IP originates from, is where the NCSoft-developed MMORPG has made most of its money, bringing in more than $2 billion to date, or 89.5 percent of revenue. App Store players, meanwhile, have paid out nearly $344 million, or 15 percent. Lineage 2: Revolution, meanwhile, launched on December 14 2016, has taken $1.7 billion, or 43 percent.Įighty-five percent of gross revenue for Lineage M came from Android users, who have spent more than $1.9 billion in the game. Lineage M, released on June 21 2017, has been the most successful of the two titles, hitting nearly $2.3 billion from player spending, or 57 percent of the combined total. MMORPGs Lineage M by NCSoft and Lineage 2: Revolution by Netmarble have surpassed a combined $4 billion in lifetime gross revenue on mobile across the App Store and Google Play, according to Sensor Tower Store Intelligence estimates. ![]()
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